Buy Dissociatives For Their Known Value Beyond Recreation!

10 Responses

  1. dissociated says:

    How do dissociatives work?

    Though the mechanisms differ from substance to substance, the majority of dissociatives work by either blocking or severely reducing the communication between the areas of the brain responsible for the conscious mind from the other parts of the brain. Most act as NMDA receptor antagonists, limiting the brain’s ability to communicate both with the body and between its various regions.

    Hallucinations and hallucinatory effects are frequent side effects of dissociatives. These might include sensory hallucinations, a dream or trance-like state, or even total sensory deprivation. It is believed that this is due to the lack of information flowing between brain regions – faced with a lack of stimulation, the different parts of the brain ‘fill in the gaps’ with dreamlike imagery and experiences.

    Selective dissociatives

    A small subset of dissociatives are considered to be ‘highly selective’, meaning that they have a much stronger effect on the parts of the brain responsible for the dissociative state than for other, non-related neural receptors.

    Non-selective dissociatives

    Most dissociatives, though, are not strongly selective. Many have powerful effects on the opioid and / or dopamine receptors, and produce greater or lesser degrees of euphoria as well as the dissociative state. They also tend to have similar side effects to opioids, including analgesia, anaesthesia, sedation, amnesia, ataxia and (perhaps most dangerous) respiratory depression.

    Effects of dissociatives

    This is a fairly broad category of substances, each of which works in slightly different ways, so there is no ‘hard and fast list of effects’. That being said, though, the group is defined by its effects rather than by its structure or mechanism, so there are many held in common by most dissociatives.

    Some (but not all) common effects for dissociatives include:

    Sensory Dissociation (obviously)
    Anaesthesia without loss of consciousness
    Hallucination
    Depersonalisation
    Derealisation
    Mania
    Catalepsy
    Analgesia
    Amnesia
    Like most psychoactive substances, the effects of many dissociatives are highly dosage-dependent. There is a distinction between an ‘anaesthetic dose’ and a ‘sub-anaesthetic’ dose, with the lower dosage more commonly producing the hallucinogenic or psychedelic effects.

    The Recreational Use of Dissociatives

    Many dissociatives and their nearest derivatives are considered illegal or semi-legal in the United States, the EU and many other parts of the world due to their long history of recreational use and abuse.

    Ketamine (Quaalude) and nitrous oxide gas are both common dissociatives, and are still used as ‘club drugs’ today. Phencyclidine (PCP) is still sold on the street, and is rather infamous for its deleterious effects.

    Other substances are not illegal per-se, but are misused to enhance their dissociative effect. Both chloroform and ether were considered ‘party drugs’ historically, and DXM (Dextromethorphan) containing cough syrup is often take in a much higher than recommended dosage to trigger its dissociative side effects deliberately.

  2. worthwhile Research Chemicals says:

    Honestly, you’re pretty much right there. I’d choose MXE over street K, just because most out of the K out there these days is godawful (I IM’d 2 points a few weeks ago and just got a little wonky, disgraceful. Back in the day 1pt snorted would have you off in space talking to Krishna), but given the choice between the two in pure form, there’d be no contest. Same for 4-mmc (or any of the dozens of empathogen RC’s) v. MDMA, or MDPV etc. v coke/meth.

    The only ones they’ve gotten right are the benzos, but I guess maybe a benzo is pretty hard to fuck up, because otherwise you’re right. I was wondering about this myself the other day, why, with all the infinite possibilities of science, have they not struck on a chemical better than the originals? If I had to make a wild guess, I’d think that most of the groups synthing these things are just adding a molecule here or there then selling it off as soon as they hit something remotely recreational, but maybe a truly perfect drug is a hard to come by. Maybe MDMA, or K, or whatever, really are one in a million, and that’s why they floated to the top in the black market.

  3. value of Dissociatives [Long] says:

    I agree with the analytical introspection that comes with DXM. I can detach from my ego and ponder questions like what humans are and other questions that would usually scare me.

  4. antidepressant effec says:

    Dissociation and the thought patterns that come with it are certainly quite useful for getting almost a 3rd party view of yourself, which can be quite helpful.

    Their antidepressant effect is also a godsend, not just for it in and of itself, but also as you said, they allow you to improve and treat the causes of depression during the antidepressant afterglow.

  5. Methoxetamine: The “Legal” Dissociative That Is Stronger & More Dangerousby Terry Gotham says:

    Now that everyone is slowly filtering back into the default world, I wanted to mention a somewhat warped trend that the dance music community has been coping with for the last couple of years. Peeps search for replacements to a select illegal drug of choice, then optimize efficacy when they find one. While this sounds kind of harmless, any of our regular readers will be aware of the issues I’ve discussed surrounding legal highs & novel psychoactive substances. Today I want to talk Methoxetamine or MXE, the latest Ketamine substitute you probably saw someone sniff without knowing on playa.

    As Ketamine was cut by dealers worldwide, people started looking for replacement substances. Additionally, if your K dealer was ever busted, you needed another source. What people found was Methoxetamine, a much stronger disassociative powder that has provided some crazy trips and terrifying experiences for the heavy users among us. Also, apparently the M-Ket Holes the heavy doses induce result in people “standing upright, totally zoned out, with pants full of shit.” That’s right, all the fun of a K-hole, now with new & improved involuntary bowel evacuation!

  6. Ketamine’s effects says:

    Central to the problem is that Ketamine’s effects are well known & we’ve got a ton of research on the stuff. MXE, MXP & the other substitutes for Ketamine aren’t cleared for human consumption, nor do we have a good understanding of their array of symptoms. We have good longitudinal data about using Ketamine for months or even years on end. We don’t even have data on what happens if you take this stuff every night over a weekend, much less if you build it into your annual drug consumption. This makes MXE potentially more dangerous than K. Ask anyone who has seen someone ruin their lives on Ketamine and they can tell you just how dangerous Ketamine is. So, to say that this stuff is more dangerous, seems like a bit of a stretch, but the proof is out there for people willing to look.

  7. The “Legal” Dissociative says:

    Such an empty article. Did you talk to anyone who enjoys MXE or look for any science around MXE?

    This is one of my favorite substances, and I’ve had some of the most enjoyable conversations on it. It’s stimulating, and generally cognitively clear, without the fog and anti-social effects often associated with ketamine. There is little or no hangover, perhaps even a positive one. While the drug is chemically related to ketamine, the effects are wildly different.

    I’ve done MXE with many, many, many people and never once had anyone shit themselves, and almost every person has loved the experience.

    This blog bags on lots of people for publishing poorly researched or deceptive drivel. How about holding yourself to the same standard! You seem to have simply googled MXE and relied on anti-drug propaganda and media hysteria without doing a moment of substantive research.

    When you spread misinformation about drugs, you harm everyone. You should know better, being an advocate for drug decriminalization and education.

    Update this article with some reliable information! Please!

  8. Psychoactive Drugs says:

    A psychoactive drug is a chemical that changes our states of consciousness, and particularly our perceptions and moods. These drugs are commonly found in everyday foods and beverages, including chocolate, coffee, and soft drinks, as well as in alcohol and in over-the-counter drugs, such as aspirin, Tylenol, and cold and cough medication. Psychoactive drugs are also frequently prescribed as sleeping pills, tranquilizers, and antianxiety medications, and they may be taken, illegally, for recreational purposes. As you can see in Table 5.1 “Psychoactive Drugs by Class”, the four primary classes of psychoactive drugs are stimulants, depressants, opioids, and hallucinogens.

    Psychoactive drugs affect consciousness by influencing how neurotransmitters operate at the synapses of the central nervous system (CNS). Some psychoactive drugs are agonists, which mimic the operation of a neurotransmitter; some are antagonists, which block the action of a neurotransmitter; and some work by blocking the reuptake of neurotransmitters at the synapse.

  9. affeine, Nicotine, Cocaine, and Amphetamines says:

    A stimulant is a psychoactive drug that operates by blocking the reuptake of dopamine, norepinephrine, and serotonin in the synapses of the CNS. Because more of these neurotransmitters remain active in the brain, the result is an increase in the activity of the sympathetic division of the autonomic nervous system (ANS). Effects of stimulants include increased heart and breathing rates, pupil dilation, and increases in blood sugar accompanied by decreases in appetite. For these reasons, stimulants are frequently used to help people stay awake and to control weight.

    Used in moderation, some stimulants may increase alertness, but used in an irresponsible fashion they can quickly create dependency. A major problem is the “crash” that results when the drug loses its effectiveness and the activity of the neurotransmitters returns to normal. The withdrawal from stimulants can create profound depression and lead to an intense desire to repeat the high.

    Caffeine is a bitter psychoactive drug found in the beans, leaves, and fruits of plants, where it acts as a natural pesticide. It is found in a wide variety of products, including coffee, tea, soft drinks, candy, and desserts. In North America, more than 80% of adults consume caffeine daily (Lovett, 2005). Caffeine acts as a mood enhancer and provides energy. Although the U.S. Food and Drug Administration lists caffeine as a safe food substance, it has at least some characteristics of dependence. People who reduce their caffeine intake often report being irritable, restless, and drowsy, as well as experiencing strong headaches, and these withdrawal symptoms may last up to a week. Most experts feel that using small amounts of caffeine during pregnancy is safe, but larger amounts of caffeine can be harmful to the fetus (U.S. Food and Drug Administration, 2007).

    Nicotine is a psychoactive drug found in the nightshade family of plants, where it acts as a natural pesticide. Nicotine is the main cause for the dependence-forming properties of tobacco use, and tobacco use is a major health threat. Nicotine creates both psychological and physical addiction, and it is one of the hardest addictions to break. Nicotine content in cigarettes has slowly increased over the years, making quitting smoking more and more difficult. Nicotine is also found in smokeless (chewing) tobacco.

    People who want to quit smoking sometimes use other drugs to help them. For instance, the prescription drug Chantix acts as an antagonist, binding to nicotine receptors in the synapse, which prevents users from receiving the normal stimulant effect when they smoke. At the same time, the drug also releases dopamine, the reward neurotransmitter. In this way Chantix dampens nicotine withdrawal symptoms and cravings. In many cases people are able to get past the physical dependence, allowing them to quit smoking at least temporarily. In the long run, however, the psychological enjoyment of smoking may lead to relapse.

    Cocaine is an addictive drug obtained from the leaves of the coca plant. In the late 19th and early 20th centuries, it was a primary constituent in many popular tonics and elixirs and, although it was removed in 1905, was one of the original ingredients in Coca-Cola. Today cocaine is taken illegally as recreational drug.

  10. Slowing Down the Brain With Depressants: Alcohol, Barbiturates and Benzodiazepines, and Toxic Inhalants says:

    In contrast to stimulants, which work to increase neural activity, a depressant acts to slow down consciousness. A depressant is a psychoactive drug that reduces the activity of the CNS. Depressants are widely used as prescription medicines to relieve pain, to lower heart rate and respiration, and as anticonvulsants. Depressants change consciousness by increasing the production of the neurotransmitter GABA and decreasing the production of the neurotransmitter acetylcholine, usually at the level of the thalamus and the reticular formation. The outcome of depressant use (similar to the effects of sleep) is a reduction in the transmission of impulses from the lower brain to the cortex (Csaky & Barnes, 1984).

    The most commonly used of the depressants is alcohol, a colorless liquid, produced by the fermentation of sugar or starch, that is the intoxicating agent in fermented drinks. Alcohol is the oldest and most widely used drug of abuse in the world. In low to moderate doses, alcohol first acts to remove social inhibitions by slowing activity in the sympathetic nervous system. In higher doses, alcohol acts on the cerebellum to interfere with coordination and balance, producing the staggering gait of drunkenness. At high blood levels, further CNS depression leads to dizziness, nausea, and eventually a loss of consciousness. High enough blood levels such as those produced by “guzzling” large amounts of hard liquor at parties can be fatal. Alcohol is not a “safe” drug by any means—its safety ratio is only 10.

    Alcohol use is highly costly to societies because so many people abuse alcohol and because judgment after drinking can be substantially impaired. It is estimated that almost half of automobile fatalities are caused by alcohol use, and excessive alcohol consumption is involved in a majority of violent crimes, including rape and murder (Abbey, Ross, McDuffie, & McAuslan, 1996). Alcohol increases the likelihood that people will respond aggressively to provocations (Bushman, 1993, 1997; Graham, Osgood, Wells, & Stockwell, 2006). Even people who are not normally aggressive may react with aggression when they are intoxicated. Alcohol use also leads to rioting, unprotected sex, and other negative outcomes.

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