Penthedrone Legal Research Chemical

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  1. n-ethyl-pentedrone and NEP says:

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    Ethyl-pentedrone (also known as n-ethyl-pentedrone and NEP) is a stimulant research chemical belonging to the cathinone class. Ethyl-pentedrone’s stimulation is believed to be caused by its affinity as an NDRI (norepinephrine-dopamine reuptake inhibitor); however, there have been no scientific studies confirming this. It may also act as a serotonin reuptake inhibitor or releasing agent in moderate to high doses, but this is only speculation.

    Ethyl-pentedrone is closely related to pentedrone, with an added ethyl-group on the carbon chain containing the nitrogen. This addition makes it about 3x as potent as pentedrone. Ethyl-pentedrone is also closely related to ethyl-hexedrone, and is likely very similar in effects.

    Ethyl-pentedrone first became known in the research chemical market during 2016. Little research exists about ethyl-pentedrone and its parent compound pentedrone. All dosage information found on the internet should be treated with caution.

  2. NEP(N-Ethyl-nor-pentedrone) says:

    Subjective effects:

    The effects listed below are based upon the subjective effects index and personal experiences of PsychonautWiki contributors. The listed effects should be taken with a grain of salt and will rarely (if ever) occur all at once, but heavier doses will increase the chances and are more likely to induce a full range of effects. Likewise, adverse effects become much more likely on higher doses and may include injury or death.

  3. Toxicity and harm potential says:

    The toxicity and long-term health effects of recreational NEP use do not seem to have been studied in any scientific context and the exact toxic dosage is unknown. This is because NEP has an extremely brief history of human usage. Early anecdotal evidence from people who have tried NEP within the community suggests that there do not seem to be any negative health effects attributed to simply trying this substance at low to moderate doses by itself and using it in a sparing and controlled fashion (but nothing can be completely guaranteed)

    It is strongly recommended that one use harm reduction practices when using this substance.

  4. Dangerous interactions says:

    Although many psychoactive substances are safe on their own, they can become dangerous and even life-threatening when combined with other substances. The list below contains some common potentially dangerous combinations, but may not include all of them. Certain combinations may be safe in low doses of each but still increase the potential risk of death. Independent research should always be done to ensure that a combination of two or more substances is safe before consumption.

    Stimulants – NEP can be potentially dangerous in combination with other stimulants as it can increase one’s heart rate and blood pressure to dangerous levels.
    25x-NBOMe – Both the NBOMe series and this compound induce powerful stimulation and their interaction may cause severe side effects. These can include thought loops, seizures, increased blood pressure, vasoconstriction, increased heart rate, and heart failure (in extreme cases).
    Alcohol – It is dangerous to combine alcohol, a depressant, with stimulants due to the risk of excessive intoxication. Stimulants decrease the sedative effect of alcohol which is the main factor most people consider when determining their level of intoxication. Once the stimulant wears off, the effects of alcohol will be significantly increased, leading to intensified disinhibition as well as respiratory depression. If combined, one should strictly limit themselves to only drinking a certain amount of alcohol per hour.
    DXM – This combination may cause increased heart rate and panic attacks.
    MXE – Increased heart rate and blood pressure may occur.
    Tramadol – This combination can increase the risk of seizures.
    MDMA – The neurotoxic effects of MDMA may be increased when combined with amphetamine and other stimulants.
    MAOIs – This combination may increase the amount of neurotransmitters such as dopamine to dangerous or even fatal levels. Examples include syrian rue, banisteriopsis caapi, 2C-T-2, 2C-T-7, αMT, and some antidepressants.[6]
    Cocaine – This combination may increase strain on the heart to dangerous, potentially fatal levels.

  5. Dangerous interactions says:

    Although many psychoactive substances are safe on their own, they can become dangerous and even life-threatening when combined with other substances. The list below contains some common potentially dangerous combinations, but may not include all of them. Certain combinations may be safe in low doses of each but still increase the potential risk of death. Independent research should always be done to ensure that a combination of two or more substances is safe before consumption.

    Stimulants – NEP can be potentially dangerous in combination with other stimulants as it can increase one’s heart rate and blood pressure to dangerous levels.
    25x-NBOMe – Both the NBOMe series and this compound induce powerful stimulation and their interaction may cause severe side effects. These can include thought loops, seizures, increased blood pressure, vasoconstriction, increased heart rate, and heart failure (in extreme cases).
    Alcohol – It is dangerous to combine alcohol, a depressant, with stimulants due to the risk of excessive intoxication. Stimulants decrease the sedative effect of alcohol which is the main factor most people consider when determining their level of intoxication. Once the stimulant wears off, the effects of alcohol will be significantly increased, leading to intensified disinhibition as well as respiratory depression. If combined, one should strictly limit themselves to only drinking a certain amount of alcohol per hour.
    DXM – This combination may cause increased heart rate and panic attacks.
    MXE – Increased heart rate and blood pressure may occur.
    Tramadol – This combination can increase the risk of seizures.
    MDMA – The neurotoxic effects of MDMA may be increased when combined with amphetamine and other stimulants.
    MAOIs – This combination may increase the amount of neurotransmitters such as dopamine to dangerous or even fatal levels. Examples include syrian rue, banisteriopsis caapi, 2C-T-2, 2C-T-7, αMT, and some antidepressants.[6]
    Cocaine – This combination may increase strain on the heart to dangerous, potentially fatal levels.

  6. References says:

    Liu, C., Jia, W., Li, T., Hua, Z., & Qian, Z. (n.d.). Identification and analytical characterization of nine synthetic cathinone derivatives N-ethylhexedrone, 4-Cl-pentedrone, 4-Cl–EAPP, propylone, N-ethylnorpentylone, 6-MeO-bk-MDMA, -PiHP, 4-Cl–PHP, and 4-F–PHP.
    Treatment for amphetamine psychosis | [1]
    Treatment for amphetamine psychosis | [2]
    Hofmann FG (1983). A Handbook on Drug and Alcohol Abuse: The Biomedical Aspects (2nd ed.). New York: Oxford University Press. p. 329. ISBN 9780195030570.
    Treatment for amphetamine psychosis | [3]
    Gillman, P. K. (2005). Monoamine oxidase inhibitors, opioid analgesics and serotonin toxicity. British Journal of Anaesthesia, 95(4), 434-441.
    Gillman, P. K. (2005). Monoamine oxidase inhibitors, opioid analgesics and serotonin toxicity. British Journal of Anaesthesia, 95(4), 434-441.
    United Kingdom. (2010). Misuse of Drugs Act 1971 (S.I. 2010/1207). London: The Stationery Office Limited. Retrieved February 9, 2018, from

  7. Dangerous interactions says:

    Although many psychoactive substances are safe on their own, they can become dangerous and even life-threatening when combined with other substances. The list below contains some common potentially dangerous combinations, but may not include all of them. Certain combinations may be safe in low doses of each but still increase the potential risk of death. Independent research should always be done to ensure that a combination of two or more substances is safe before consumption.

    Stimulants – Pentedrone can be potentially dangerous in combination with other stimulants as it can increase one’s heart rate and blood pressure to dangerous levels.
    25x-NBOMe – Both the NBOMe series and this compound induce powerful stimulation and their interaction may cause severe side effects. These can include thought loops, seizures, increased blood pressure, vasoconstriction, increased heart rate, and heart failure (in extreme cases).
    Alcohol – It is dangerous to combine alcohol, a depressant, with stimulants due to the risk of excessive intoxication. Stimulants decrease the sedative effect of alcohol which is the main factor most people consider when determining their level of intoxication. Once the stimulant wears off, the effects of alcohol will be significantly increased, leading to intensified disinhibition as well as respiratory depression. If combined, one should strictly limit themselves to only drinking a certain amount of alcohol per hour.
    DXM – This combination may cause increased heart rate and panic attacks.
    MXE – Increased heart rate and blood pressure may occur.
    Tramadol – This combination can increase the risk of seizures.
    MDMA – The neurotoxic effects of MDMA are generally believed to be increased when combined with amphetamine and other stimulants.
    MAOIs – This combination may increase the amount of neurotransmitters such as dopamine to dangerous or even fatal levels. Examples include syrian rue, banisteriopsis caapi, 2C-T-2, 2C-T-7, αMT, and some antidepressants.[8]
    Cocaine – This combination may increase strain on the heart to dangerous levels

  8. Toxicity says:

    The toxicity and long-term health effects of recreational pentedrone use do not seem to have been studied in any scientific context and the exact toxic dosage is unknown. This is because pentedrone has a very short history of human usage. Early anecdotal evidence from people who have tried pentedrone within the community suggests that there do not seem to be any negative health effects attributed to simply trying this substance at low to moderate doses by itself and using it in a sparing and controlled fashion (but nothing can be completely guaranteed).

    It is strongly recommended that one use harm reduction practices when using this substance.

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