The Truth about Mexedrone Research Chemical

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12 Responses

  1. 3-methoxy-2-(methylamino)-1-(p-tolyl)propan-1-one says:

    Chemistry
    Mexedrone, or 3-methoxy-2-(methylamino)-1-(p-tolyl)propan-1-one, is a synthetic molecule of the cathinone family. Cathinones are structurally similar to amphetamines. They contain a phenethylamine core featuring a phenyl ring bound to an amino (NH2) group through an ethyl chain with an additional methyl substitution at Rα. Amphetamines and cathinones are alpha-methylated phenethylamines. Cathinones contain an additional ketone group bonded at R1.

    Mexedrone contains additional methyl substitutions at RN (similar to MDMA and methamphetamine) and R4 of its phenyl ring. Mexedrone is named for the methoxy group (C3O-) bound to the methyl group located at Rα. Mexedrone is closely analogous to mephedrone, however, mephedrone lacks the additional methoxy group bonded to the α-methyl group.

    Pharmacology
    Given its similar subjective effects and chemical structure to mephedrone, this compound is likely (but not confirmed) to act as a releasing agent and a reuptake inhibitor for monoamine neurotransmitters such as serotonin, dopamine and noradrenaline. This increase in neurotransmitters provides an explanation for the euphoric and stimulating effects induced by this experience. Anecdotal reports often state that mexedrone is more sedating than stimulating, which suggests it may release more serotonin than dopamine in a fashion that is similar to MDAI.

  2. MCat2 (Mephedrone Replacement) says:

    Without knowing the chemical formula, this is completely meaningless. If it’s just going to be some undisclosed branded product, I wouldn’t touch it with a barge pole personally. Also, there’s nothing to indicate that it will even be UK legal.

  3. MCat2 says:

    I’m removing the link but leaving this up for information. If anyone even considers that this is in any way genuine then they are misguided, delusional and frankly idiotic. This is a scam from head to toe there is no replacement it doesnt exist and certainly would not be legal its the biggest load of utter rubbish that is doing the worst thing preying on vulnerable people or just people who know no better. If anyone from this forum orders this mystery powder I will be really disappointed. The domain was registered 2 days ago which speaks volumes. This blatant and deliberate attempt to defraud people makes me really annoyed. They are collecting email addresses and offering 100 free samples but cant disclose the highly guarded chemical, which I can safely now reveal as bullshit.

    Think people use your heads…..

  4. MEXEDRONE says:

    BUY IT NOW: Chem has Mexedrone Crystal in stock ready to sell, a EU legal Cathinone

    Mexedrone is 100% legal across Europe (NOT including UK).

    The chemical name is: 3methoxy-2 (methylamino)-1-(p-tolyl)propan-1-one or AKA: 4-mmc-oMe

    Research Chemicals such as Mexedrone are for research only. Not human consumption!

  5. Physical effects says:

    Physical euphoria
    Tactile enhancement
    Sedation – The biggest difference between mexedrone and mephedrone is that it primarily results in moderate sedation over stimulation and can therefore discourage physical activities such as running, dancing or climbing.
    Spontaneous physical sensations – The “body high” of mexedrone can be described as a mild soft and warm tingling sensation that encompasses the entire body. This sensation maintains a consistent presence that steadily rises with the onset and hits its limit once the peak has been reached.
    Dehydration
    Vibrating vision – At high doses, a person’s eyeballs may begin to spontaneously wiggle back and forth in a rapid motion, causing the vision to become blurry and temporarily out of focus. This is a condition known as nystagmus.
    Increased perspiration
    Temperature regulation suppression
    Teeth grinding – This component can be considered to be less intense when compared with that of MDMA.

  6. Cognitive effects says:

    Euphoria – Mild emotional euphoria and feelings of happiness are present within mexedrone and are likely a direct result of serotonin and dopamine release.
    Thought acceleration
    Thought connectivity

  7. After effects says:

    The effects which occur during the offset of a stimulant experience generally feel negative and uncomfortable in comparison to the effects which occurred during its peak. This is often referred to as a “comedown” and occurs because of neurotransmitter depletion. Its effects commonly include:

    Anxiety
    Cognitive fatigue
    Depression
    Irritability
    Motivation suppression
    Thought deceleration
    Wakefulness

  8. Tolerance and addiction potential says:

    As with other stimulants, the chronic use of mexedrone can be considered moderately addictive with a high potential for abuse and is capable of causing psychological dependence among certain users. When addiction has developed, cravings and withdrawal effects may occur if a person suddenly stops their usage.

    Tolerance to many of the effects of mexedrone develops with prolonged and repeated use. This results in users having to administer increasingly large doses to achieve the same effects. After that, it takes about 3 – 7 days for the tolerance to be reduced to half and 1 – 2 weeks to be back at baseline (in the absence of further consumption). Mexedrone presents cross-tolerance with all dopaminergic stimulants, meaning that after the consumption of mexedrone all stimulants will have a reduced effect.

  9. Serotonin syndrome risk says:

    Combinations in the list below may increase the amount of neurotransmitters such as serotonin and dopamine to dangerous or even fatal levels.

    MAOIs such as syrian rue, banisteriopsis caapi, 2C-T-2, 2C-T-7, αMT, and some antidepressants[4]
    Serotonin releasers such as MDMA, 4-FA, MDAI and αMT
    Selective serotonin re-uptake inhibitors (SSRIs)
    Serotonin-norepinephrine reuptake inhibitors (SNRIs)
    5-HTP

  10. 1P-LSD 100mcg Blotters says:

    1-propionyl-LSD also known as 1P-LSD or 1-propionyl-lysergic acid diethylamide is a new uncontrolled LSD analogue supplied in 100µg blotters for convenient research.

    This product is sold only for research uses in laboratory settings. Those who work with it are advised to wear the appropriate safety gear and follow standard safety protocols while handling it.

    Strictly not for human consumption if consumed seek immediate medical assistance

    1P-LSD 100mcg Blotters can only be ordered if you are over 18 years of age.

    Please ensure that 1P-LSD 100mcg Blotters is NOT controlled in the country/state to which you wish it to be delivered.

    1P-LSD 100mcg Blotters is not for human consumption.

  11. Synthacaine Powder says:

    Synthacaine Powder has, in the past, had a rather bad reputation in the research industry, but that’s largely because of how many companies are selling very low quality samples of it.

    We work closely with a reputable laboratory to ensure that all of our synthacaine produce is at least 98 percent pure. We do not release the exact formulation of this product because it is a proprietary blend.

    Synthacaine Powder is an amazing blend of some of our best-selling research chemicals. Synthacaine contains Ethyl-hexedrone and Lidocaine.

    Synthacaine Powder can only be ordered if you are over 18 years of age.

    Please ensure that Synthacaine Powder is NOT controlled in the country/state to which you wish it to be delivered.

  12. Computational Resources from NCBI's Structure Group says:

    A centralized page providing access and links to resources developed by the Structure Group of the NCBI Computational Biology Branch (CBB). These resources cover databases and tools to help in the study of macromolecular structures, conserved domains and protein classification, small molecules and their biological activity, and biological pathways and systems.

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